Locally advanced breast cancer has spread beyond the breast to the chest wall or the skin of the breast or too many lymph nodes in the underarm area, but not to other organs and it refers to the most advanced-stage non-metastatic breast tumors and includes a wide variety of clinical scenarios. These tumors remain a difficult clinical problem as most patients with the locally advanced disease will experience disease relapse and eventual death. The prognostic factors for locally advanced tumors are similar to the prognostic factors for earlier stage breast cancer, with lymph node status and tumor size having the strongest effects on survival. The treatment of locally advanced breast cancer requires a combination of systemic chemotherapy, surgery, and radiotherapy to optimize the chance of cure. The earliest therapy for locally advanced breast cancer was a radical mastectomy. Inflammatory Breast Cancer can also be hard to see on a mammogram. It’s often spread throughout the breast or it may only show up as a sign of inflammation (such as skin thickening). About 30 percent of women with IBC have metastasis when they are diagnosed; it means cancer has spread beyond the breast to other organs in the body such as the bones, lungs, liver or brain.